| Chris Ray | Elbow | 15-day DL. Out for the season |
| Adam Loewen | Elbow | 15-day DL. Out for the season |
| Matt Albers | Shoulder | 15-day DL. Might be out for the season |
| Greg Aquino | Hamstring | 15-day DL. Out until at least early August |
| Danys Báez | Elbow | 60-day DL. Out for the season |
| Troy Patton | Shoulder | 60-day DL. Out for the season |
| Jamie Walker | Elbow | 15-day DL. Out until at least late July |
| Jim Hoey | Biceps | 15-day DL. Out for the season |
| David Aardsma | Groin | 15-day DL. Out until at least early August |
| Jon Lester | Shin | Probable for July 27 start vs. N.Y. Yankees |
| Julio Lugo | Quadriceps | 15-day DL. Out until at least late July |
| David Ortiz | Wrist | 15-day DL. Expected to return for July 25-27 series vs. N.Y. Yankees |
| Manny Ramírez | Knee | Might return for July 25-27 series vs. N.Y. Yankees |
| Bartolo Colón | Back | 15-day DL. Out until at least late July |
| Curt Schilling | Shoulder | 15-day DL. Out for the season |
| Jorge Posada | Shoulder | 15-day DL. Out until at least mid-August |
| Andrew Brackman | Elbow | 60-day DL. Out for the season |
| Chien-Ming Wang | Foot | 60-day DL. Out until at least early September |
| Carl Pavano | Elbow | 60-day DL. Out until at least early August |
| Jonathan Albaladejo | Elbow | 60-day DL. Might be out for the season |
| Brian Bruney | Foot | 60-day DL. On Triple-A rehab assignment |
| Phil Hughes | Rib | 60-day DL. Out until at least mid-August |
| Hideki Matsui | Knee | 15-day DL. Out until at least early August |
| Humberto Sánchez | Elbow | 60-day DL. On Class A rehab assignment |
| Vernon Wells | Hamstring | 15-day DL. Out until at least mid August |
| Casey Janssen | Shoulder | 60-day DL. Out for the season |
| Aaron Hill | Concussion | 15-day DL. Out until at least late July |
| Jeremy Accardo | Forearm | 15-day DL. Out until at least early August |
| Frank Thomas | Quadriceps | 15-day DL. Out until at least late July |
| Shannon Stewart | Ankle | 15-day DL. Out until at least late July |
| Dustin McGowan | Shoulder | 15-day DL. Out until at least late August |
| Joe Crede | Back | Questionable for July 25-27 series at Detroit |
| Andrew Sisco | Elbow | 60-day DL. Out for the season |
| Travis Hafner | Shoulder | 15-day DL. Out until at least early August |
| Josh Barfield | Finger | 15-day DL. Out until at least early August |
| Fausto Carmona | Hip | 15-day DL. On Double-A rehab assignment. Expected to return for July 26 start vs. Minnesota |
| Jake Westbrook | Elbow | 60-day DL. Out for the season |
| Scott Elarton | Personal | 60-day DL. Out for the season |
| Víctor Martínez | Elbow | 15-day DL. Out until at least mid-August |
| Jeremy Bonderman | Shoulder | 15-day DL. Might be out for the season |
| Vance Wilson | Elbow | 15-day DL. Out for the season |
| John Bale | Shoulder, hand | 60-day DL. On Double-A rehab assignment |
| Mark Teahen | Back | Questionable for July 25-27 vs. Tampa Bay |
| Brett Tomko | Elbow | 15-day DL. Out until at least early August |
| Jimmy Gobble | Back | 15-day DL. Out until at least mid-August |
| Alberto Callaspo | Undisclosed | 15-day DL. Out until at least late July |
| Luke Hudson | Biceps | 60-day DL. Out until at least mid-August |
| Joey Gathright | Shoulder | 15-day DL. Out until at least mid-August |
| Michael Cuddyer | Finger | 15-day DL. Out until at least early August |
| Adam Everett | Shoulder | 15-day DL. On Class A rehab assignment |
| Pat Neshek | Elbow | 60-day DL. Out for the season |
| Mike Napoli | Shoulder | 15-day DL. Out until at least early August |
| Jeff Mathis | Shoulder | 15-day DL. Out until at least late July |
| Kelvim Escobar | Shoulder | 60-day DL. Out for the season |
| Torii Hunter | Personal | Out until at least July 25-27 series at Baltimore |
| Jered Weaver | Back | Probable for July 28 at Boston |
| Daric Barton | Head, neck | 15-day DL. Out until at least early August |
| Mike Sweeney | Knee | 15-day DL. Out until at least late July |
| Joey Devine | Elbow | 15-day DL. Out until at least late July |
| Keith Foulke | Shoulder | 15-day DL. Out until at least late July |
| Eric Chávez | Shoulder | 15-day DL. Out until at least early August |
| Mark Ellis | Shoulder | Questionable for July 25-27 series vs. Texas |
| Carlos Silva | Back | Questionable for July 26 start at Toronto |
| Jeff Clement | Hand | Questionable for July 25-27 series at Toronto |
| Erik Bedard | Shoulder | 15-day DL. Out until at least early August |
| Mike Morse | Shoulder | 15-day DL. Out for the season |
| Brandon McCarthy | Elbow | 15-day DL. On Class A rehab assignment |
| Joaquín Benoit | Shoulder | 15-day DL. Out until at least late July |
| John Rheinecker | Arm | 60-day DL. Might be out for the season |
| Jason Jennings | Forearm | 15-day DL. Out for the season |
| Kason Gabbard | Elbow | 15-day DL. Out for the season |
| A.J. Murray | Shoulder | 15-day DL. Out until at least late July |
| Gerald Laird | Hamstring | 15-day DL. On Triple-A rehab assignment. Out until at least late July |
| Kevin Millwood | Questionable | Questionable for July 29 start vs. Toronto |
| John Smoltz | Shoulder | 60-day DL. Out for the season |
| Tim Hudson | Elbow | Questionable for July 29 start vs. St. Louis |
| Tom Glavine | Elbow | 15-day DL. Out until at least mid-August |
| Matt Diaz | Knee | 15-day DL. On Triple-A rehab assignment |
| Jeff Bennett | Shoulder | 15-day DL. Out until at least early August |
| Mike Hampton | Pectoral, groin | 15-day DL. Out until at least early August |
| Chipper Jones | Thigh | Questionable for July 25-27 series at Philadelphia |
| Anthony Lerew | Elbow | 60-day DL. On Class A rehab assignment |
| Manny Acosta | Hamstring | 15-day DL. Out until at least early August |
| Peter Moylan | Elbow | 60-day DL. Out for the season |
| Matt Treanor | Hip | 15-day DL. Might begin Class A rehab assignment July 26 |
| Andrew Miller | Knee | 15-day DL. Out until at least early August |
| Sergio Mitre | Forearm | 60-day DL. Out for the season |
| Anibal Sánchez | Shoulder | 60-day DL. On Class A rehab assignment. Might return for July 28 start vs. N.Y. Mets |
| Harvey García | Shoulder | 60-day DL. Out for the season |
| Brett Carroll | Shoulder | 60-day DL. Out until at least late August |
| Lee Gardner | Elbow | 60-day DL. Out for the season |
| Henry Owens | Shoulder | 60-day DL. Might be out for the season |
| Aaron Boone | Calf | 15-day DL. Out until at least late July |
| Dmitri Young | Illness | 15-day DL. Out until at least early August |
| Shawn Hill | Elbow | 15-day DL. Out until at least late August |
| Elijah Dukes | Knee | 15-day DL. Out until at least late August |
| Lastings Milledge | Groin | 15-day DL. On Class A rehab assignment. Might return for July 25-27 series at L.A. Dodgers |
| Ryan Wagner | Shoulder | 60-day DL. On Class A rehab assignment |
| Chad Cordero | Shoulder | 60-day DL. Out for the season |
| Nick Johnson | Wrist | 60-day DL. Out for the season |
| Matt Wise | Shoulder | 15-day DL. Out until at least late July |
| Ambiorix Burgos | Elbow | 15-day DL. Might be out for the season |
| Moisés Alou | Hamstring | 15-day DL. Out for the season |
| Tony Armas | Abdominal | 15-day DL. Out until at least late July |
| Luis Castillo | Quadriceps | 15-day DL. Out until at least late July |
| Ryan Church | Post-concussion syndrome | 15-day DL. Might begin Class A rehab assignment July 25 |
| Orlando Hernández | Foot | 15-day DL. Out until at least mid-August |
| Pedro Martínez | Shoulder, personal | Out until at least early August |
| Ángel Pagán | Shoulder | 15-day DL. Might be out for the season |
| Tom Gordon | Elbow | 15-day DL. Out until at least mid-August |
| Scott Mathieson | Elbow | 15-day DL. Out for the season |
| Mike Zagurski | Elbow | 15-day DL. Out for the season |
| Ángel Guzmán | Elbow | 60-day DL. Out for the season |
| Kerry Wood | Blister | 15-day DL. Out until at least mid-August |
| Jon Lieber | Foot | 15-day DL. Out until at least early August |
| Álex Cintrón | Hamstring | 15-day DL. Out until at least late July |
| Álex González | Knee | 60-day DL. Out for the season |
| Jared Burton | Oblique | 15-day DL. Out until at least early August |
| Josh Fogg | Face | Might return for July 29 start at Houston |
| Norris Hopper | Elbow | 60-day DL. Out for the season |
| Aaron Harang | Forearm | 15-day DL. Out until at least early August |
| Felipe Paulino | Arm | 15-day DL. Out until at least mid-August |
| Roy Oswalt | Hip, back | 15-day DL. Expected to return for July 28 start vs. Cincinnati |
| Chris Capuano | Elbow | 15-day DL. Out for the season |
| Yovani Gallardo | Knee | 15-day DL. Out until at least early September |
| Phil Dumatrait | Shoulder | 15-day DL. Out until at least mid-August |
| Matt Capps | Shoulder | 15-day DL. Out until at least early September |
| Kelvin Jiménez | Hand | 15-day DL. Out until at least early August |
| Brian Barton | Wrist | 15-day DL. Out until at least early August |
| Juan Encarnación | Eye | 60-day DL. Out for the season |
| Adam Wainwright | Finger | 15-day DL. Out until at least early August |
| Chris Carpenter | Elbow | 60-day DL. On Double-A rehab assignment |
| Chris Duncan | Neck | 15-day DL. Out until at least mid-August |
| Mark Mulder | Shoulder | 15-day DL. Out until at least mid-August |
| Josh Kinney | Elbow | 60-day DL. Might be out for the season |
| Justin Upton | Oblique | 15-day DL. Out until at least late July |
| Doug Slaten | Knee | 15-day DL. Out until at least early August |
| Eric Byrnes | Hamstring | 60-day DL. Out for the season |
| Juan Cruz | Oblique | 15-day DL. Out until at least early August |
| Orlando Hudson | Ankle | Questionable for July 25-27 series at San Francisco |
| Trot Nixon | Groin | 15-day DL. Out until at least late July |
| Ryan Spilborghs | Oblique | 15-day DL. Out until at least late July |
| Todd Helton | Back | 15-day DL. Out until at least late July |
| Jeff Francis | Shoulder | 15-day DL. Expected to make Double-A rehab start July 26 |
| Rafael Furcal | Back | 60-day DL. Out until at least late August |
| Yhency Brazobán | Shoulder | 60-day DL. Out for the season |
| Esteban Loaiza | Shoulder | 15-day DL. On Double-A rehab assignment |
| Brad Penny | Shoulder | 15-day DL. Out until at least late July |
| Jason Schmidt | Shoulder | 60-day DL. Out until at least late August |
| Tony Abreu | Groin, hip | 60-day DL. Out for the season |
| Takashi Saito | Elbow | 15-day DL. Might be out for the season |
| Gary Bennett | Foot | 60-day DL. Out until at least early August |
| Scott Proctor | Elbow | 15-day DL. Out until at least late July |
| Mark Sweeney | Hamstring | 15-day DL. On Triple-A rehab assignment |
| Juan Pierre | Knee | 15-day DL. Out until at least early August |
| Tadahito Iguchi | Shoulder | 15-day DL. Out until at least early August |
| Jim Edmonds | Knee | Questionable for July 25-27 vs. Florida |
| Kevin Cameron | Elbow | 15-day DL. On Class A rehab assignment |
| Mark Prior | Shoulder | 60-day DL. Out for the season |
| Tim Stauffer | Shoulder | 60-day DL. Out for the season |
| Scott Hairston | Hamstring | 15-day DL. Eligible to return July 29 at Houston |
| Michael Barrett | Nose | 15-day DL. Out until at least late August |
| Merkin Valdez | Elbow | 15-day DL. Out until at least late July |
| Noah Lowry | Forearm | 60-day DL. Might be out for the season |
